Journal Guide

C. elegans RDE-4 is a double-stranded RNA binding protein that has been shown to play a key role in response to foreign double-stranded RNA (dsRNA). We have used diverse tools for analysis of gene function to characterize the domain and organismal foci of RDE-4 action in C. elegans. First, we examined the focus of activity within the RDE-4 protein, by testing a series of RDE-4 deletion constructs for their ability to support dsRNA-triggered gene silencing. These assays indicated a molecular requirement for a linker region and the second dsRNA-binding domain of RDE-4, with ancillary contributions to function from the C and N terminal domains. Second, we used mosaic.

RSC Chemical Biology is a gold open access journal dedicated to publishing and disseminating exceptional, breakthrough research and high-quality reviews at the interface of chemistry and biology. We welcome contributions from across the breadth of the chemical biology field. This includes Sensing and Imaging, Bioorthogonal chemistry, Biosynthesis, Biomimetics and Bioengineering, Synthetic biology, Directed evolution, Drugs development and mechanism of action, Glycoscience, Natural products, Nucleic acids, Peptides, Phenotypic screening, Proteins (including protein-protein interactions, modifications, structure and function) We are particularly interested in reports on the application of chemical tools to probe, explore and visualize biological systems and processes to provide insights into molecular mechanisms in health and disease. We also encourage translational research that bridges chemistry and chemical biology to medicine.

Reproduction, Fertility and Development is an international journal for the publication of original and significant contributions related to scientific aspects of reproduction and development, including biology, physiology, biochemistry, endocrinology, immunology, cell biology, genetics, epigenetics, and behaviour, and the development of reproductive technologies in humans, livestock and wildlife, and in pest management. Contributions may take the form of original research articles, critical reviews, and rapid communications.Research articles should report research that addresses a fundamental question in reproductive biology. Descriptive and methodological studies will be assessed according to this criterion. In general, articles dealing with clinical or veterinary practice or the routine application of reproductive technologies are not considered. Reproduction, Fertility and Development has no page charges, and offers free colour online.

1887-The beginnings of the journalResearch in Microbiology is the direct descendant of the original Pasteur periodical entitled Annales de l'Institut Pasteur, created in 1887 by Emile Duclaux under the patronage of Louis Pasteur. The Editorial Committee included Chamberland, Grancher, Nocard, Roux and Straus, and the first issue began with Louis Pasteur's "Lettre sur la Rage" which clearly defines the spirit of the journal:"You have informed me, my dear Duclaux, that you intend to start a monthly collection of articles entitled "Annales de l'Institut Pasteur". You will be rendering a service that will be appreciated by the ever increasing number of young scientists who are attracted to microbiological studies. In your Annales, our laboratory research will of course occupy a central position, but the work from outside groups that you intend to publish will be a source of competitive stimulation for all of us."That first volume included 53 articles as well as critical reviews and book reviews. From that time on, the Annales appeared regularly every month, without interruption, even during the two world wars. Although the journal has undergone many changes over the past 100 years (in the title, the format, the language) reflecting the evolution in scientific publishing, it has consistently maintained the Pasteur tradition by publishing original reports on all aspects of microbiology.Originally founded as the " Annales de l'Institut Pasteur ", Research in Microbiology has been a leading source of up-to-date information in the field of microbiology for more than a century. It publishes papers based on original research in fundamental and applied biology of bacteria, archaea and lower eukaryotes. It covers all aspects of the microbial taxonomy, phylogeny, ecology, physiology and metabolism, molecular genetics and genomics, as well as the interactions between microbes and interactions of microbes with their environment. Research in Microbiology currently publishes 10 issues a year, including an annual Forum issue, original articles, reviews, and letters to the Editor.Indexed in Medline, Excerpta Medica / EMbase, Science Citation Index, Current Contents (Life Sciences)On-line services:For on-line submission:http://pasteur.fontismedia.com/res/ For full-text articles, abstracts, contents, references: http://www.sciencedirect.com For the journal homepage at Elsevier:http://www.elsevier.com/locate/resmic

Skeletal Muscle is a peer-reviewed, open access, online journal that publishes articles investigating molecular mechanisms underlying the biology of skeletal muscle. A wide range of skeletal muscle biology is included: development, metabolism, the regulation of mass and function, aging, degeneration, dystrophy and regeneration. The emphasis is on understanding adult skeletal muscle, its maintenance, and its interactions with non-muscle cell types and regulatory modulators. Skeletal Muscle aims to provide a venue for the publication of novel, cutting-edge research and technological developments involving the application of molecular biology, cellular biology, and biochemistry-based approaches, and to answer questions relevant to the understanding of skeletal muscle.

Steroids is an international journal devoted to original research on all aspects of steroids. Its focus is on both experimental and theoretical studies in chemistry and physiochemistry, biosynthesis, metabolism, molecular biology, physiology, pharmacology, analytical techniques, comparative endocrinology, clinical research, mode of action (including that of related peptides), and the role of steroids on growth and differentiation.Please bookmark this URL: http://www.elsevier.com/locate/steroidsBenefits to authorsWe also provide many author benefits, such as free PDFs, a liberal copyright policy, special discounts on Elsevier publications and much more. Please click here for more information on our author services.Please see our Guide for Authors for information on article submission. If you require any further information or help, please visit our support pages: http://support.elsevier.com

Structure aims to publish papers of exceptional interest in the field of structural biology. The journal strives to be essential reading for structural biologists, as well as biologists and biochemists that are interested in macromolecular structure and function. Structure strongly encourages the submission of manuscripts that present structural and molecular insights into biological function and mechanism. Other reports that address fundamental questions in structural biology, such as structure-based examinations of protein evolution, folding and/or design, will also be considered favorably. We will consider the application of any method, experimental or computational, at high or low resolution, to conduct structural investigations, as long as the method is appropriate for the biological, functional, and mechanistic question(s) being addressed. Likewise, reports describing single molecule analysis of biological mechanisms are welcome. In general, the editors encourage submission of structural studies that are validated by additional experimental systems that address structure-activity relationships, and will not consider studies that solely report structural information unless the structure under investigation is of exceptional and broad interest.Visit the Structure website to find out more - http://www.structure.org

Systems and Synthetic Biology is a new biomedical journal publishing original papers and articles on all aspects of Systems and Synthetic Biology.Systems Biology is an integrated approach to study collective behaviour of biological interactions. The grand challenge in Systems Biology is to connect molecular topography with physiological responses. Systems Biology field will realize its fullest potential once individual contributions are tied to variations in the system level behavior. The emerging field of synthetic biology combines knowledge from various disciplines including molecular biology, engineering, mathematics, and physics to design and implement new cellular behaviors. The goal of synthetic biology is both to improve our quantitative understanding of natural phenomenon as well as to foster an engineering discipline for obtaining new complex cell behaviors in a predictable and reliable fashion. Systems and Synthetic Biology will publish research articles that either advance this field as an engineering discipline or use synthetic biology to improve our scientific knowledge of existing phenomena. Publication criteriaSystems Biology* Experimental and computational studies that associate collective behavior of molecules with higher order behavior of metabolic, signaling systems and gene regulatory networks.* Experimental and computational studies that associate pathway and network contacts with behavior of organelles, cells, tissues, physiological systems and organisms.* Pathway ontology, systems and synthetic biology tools, molecular interaction databases and model databases* New experimental and mathematical methods important to systems biology.note: computational models that lead to the experimentally validated discovery of novel biological phenomenon will receive highest priority and will be treated as accelerated publicationsSynthetic Biol, ogy* Design and fabrication of unnatural biological components and systems.* Novel design of natural and synthetic parts for a designed function.* Experimental and Computational tools and techniques used in synthetic biology.Exclusion CriteriaExperimental and computational studies that describe:Sequence analysis and structure prediction.Data mining, alignment and molecular ontology.Protein structural analysis.Genome analysis and tools.Molecular and genome annotation.Sequence databases.Population dynamics and mathematical biology.Natural properties of genes and proteins.Atomic interactions in proteins & protein folding.

The EMBO Journal provides for rapid publication of full-length papers describing original research of general rather than specialist interest in molecular biology and related areas. The journal encourages and publishes articles that report novel findings of wide biological significance in the areas of development, immunology, neuroscience, plant biology, structural biology, genomic & computational biology, genome stability & dynamics, chromatin & transcription, RNA, proteins, cellular metabolism, signal transduction, cell cycle, differentiation & death, membranes & transport, cell & tissue architecture, microbiology & pathogens and molecular biology of disease.The EMBO Journal has established itself over the last two decades as one of the most influential molecular biology journals. It is highly appreciated by scientists throughout the world. This is reflected not only in the approximately similar submission rates from Europe and non-European countries, but also by the fact that leading scientists throughout the world provide the editors with expert refereeing, ensuring the high quality of articles published in The EMBO Journal. In addition, the editors are supported in the selection of papers by an active Advisory Editorial Board. The EMBO Journal is one of the most highly cited journals, reflected in its latest impact factor of 10.124*.

FEBS Journal is an international Journal devoted to the rapid publication of full-length papers covering a wide range of topics in any area of the molecular life sciences. The criteria for acceptance are originality and high quality research, which will provide novel perspectives in a specific area of research, and will be of interest to our broad readership. The Journal does not accept papers that describe the expression of specific genes and proteins or test the effect of a drug or reagent, without presenting any biological significance. Papers describing bioinformatics, modelling or structural studies of specific systems or molecules should include experimental data. FEBS Journal publishes Reviews and Minireviews on a wide range of topics, which may be solicited or submitted. In addition, the Journal publishes Special Issues that cover in detail a chosen research topic in a specific scientific field. The scope of the journal is broad and inclusive. We are particularly interested in papers in which state-of-the-art approaches are applied to bring novel insight into molecular and cellular mechanisms that underlie the functions of molecules, cells and organisms. The Journal welcomes manuscripts of an interdisciplinary and integrative nature, including systems approaches. The areas of interest of FEBS Journal include, but are not limited to: ? Biochemistry ? Bioinformatics and Computational Biology ? Developmental Biology ? Evolutionary Biology ? Enzymology and Chemical Biology ? Genomics ? Immunology ? Molecular and Cell Biology ? Molecular Microbiology ? Molecular Mechanisms in Health and Disease ? Molecular Neurobiology ? Pathogens and Infection ? Proteomics ? Signal Transduction ? Stem cell Biology ? Structural Biology ? Systems Biology and Synthetic Biology

The Journal of Biochemistry founded in 1922 publishes the results of original research in the fields of Biochemistry, Molecular Biology, Cell, and Biotechnology written in English in the form of Regular Papers or Rapid Communications. A Rapid Communication is not a preliminary note, but it is, though brief, a complete and final publication. The materials described in Rapid Communications should not be included in a later paper. The Journal also publishes short reviews (JB Review) and papers solicited by the Editorial Board.

The Journal of Gene Medicine publishes high quality original articles and reviews on the science of gene transfer and its applications in gene and cell therapy. Key areas of interest are the design and production of vectors, delivery and targeting, gene expression and regulation, preclinical studies including animal models, developmental aspects and clinical trials. The editors particularly welcome articles dealing with the methodological aspects of gene transfer in vivo, notably in the context of human studies. Papers presenting research into the mechanisms underlying gene transfer; the application and refinement of new technologies such as RNAi, stem cells and allied approaches such as DNA vaccines; or addressing more fundamental biological issues which could lead to more effective gene transfer are also encouraged. Please note that the Journal of Gene Medicine is online-only.

Devoted to advancements in nutritional sciences, The Journal of Nutritional Biochemistry presents experimental nutrition research as it relates to: biochemistry, molecular biology, toxicology, or physiology.Rigorous reviews by an international editorial board of distinguished scientists ensure publication of the most current and key research being conducted in nutrition at the cellular, animal and human level. In addition to its monthly features of critical reviews and research articles, The Journal of Nutritional Biochemistry also periodically publishes emerging issues, experimental methods, and other types of articles.Benefits to authorsWe also provide many author benefits, such as free PDFs, a liberal copyright policy, special discounts on Elsevier publications and much more. Please click here for more information on our author services.Please see our Guide for Authors for information on article submission. If you require any further information or help, please visit our support pages: http://support.elsevier.com

The Journal of Steroid Biochemistry and Molecular Biology is devoted to new experimental and theoretical developments in areas related to steroids. The Journal publishes a variety of contributions, including original articles, general and focused reviews, and rapid communications (brief articles of particular interest and clear novelty). Selected cutting-edge topics will be addressed in Special Issues managed by Guest Editors. Special Issues will contain both commissioned reviews and invited original research to provide comprehensive coverage of specific topics, and all articles will undergo rigorous peer-review prior to publication. The JSBMB publishes experimental work, review articles and letters (commentaries).Manuscripts relating to unsolved issues in genetics, molecular biology, biochemistry, structural biology, steroid chemistry, cell biology, molecular medicine, and clinical medicine, are encouraged. Both basic and clinical areas of research are within the scope of the Journal, provided they address mechanisms or yield a functional explanation of processes involving steroids. A further aim of the Journal is to provide steroid-related tools, synthesis and analysis methods, and reference data.Contributions on case studies or descriptions of new compounds should provide new functional data. Otherwise they will be not considered. Reports on translational research are encouraged.The aims of the Journal cover studies on steroid signal transduction pathways, functional annotation of genes and kinetics of metabolic pathways, as well as the creation of enduring and validated resources for metabolomics and systems biology analyses. Furthermore, the Journal also publishes results on lipid research, functional association studies or 'omics' that are instrumental in our understanding of common complex human diseases like metabolic syndrome, diabetes or obesity. Further aspects like steroid-related cancers or neurosteroids are within the scope of the Journal. The Journal aims to enhance our understanding, and the development of approaches to study, the interplay between the environment, genomes, metabolism and disease.Studies that are based on observations performed in a single cell line will not generally be viewed favourably for publication. The experiments should ideally include experiments with comparable cell lines to demonstrate generality or specificity of the effects or mechanisms.US National Institutes of Health (NIH) voluntary posting ("Public Access") policyJournal of Steroid Biochemistry and Molecular Biology and Elsevier facilitate the author's response to the NIH Public Access Policy. For more details please see the Guide for authors

The aim of this journal is to cultivate, promote and encourage advancement ofscientific dedication in the field of cell and chromosome research  in eukaryotes- physical, chemical, structural and functional. The scope of the journal has been extended further on eukaryotic genomics covering molecular genetics – both nuclear and organellar, though no doubt the emphasis will always be on Chromosome Dynamics. It is beneficial for students, teachers,research workers and all others interested in the study of cytology, genetics, molecular genomics and evolution in eukaryotic systems.

Toxicologic Pathology focuses on the multidisciplinary elements that constitute toxicologic pathology, including spontaneous and experimentally induced morphological and functional changes, environmental exposures, case reports, and risk assessment and investigative techniques. The journal publishes original articles, symposia papers, brief communications, current topic reviews, current issues, and fast-track articles.

Traffic encourages and facilitates the publication of papers covering the cell biology of intracellular transport in health and disease. Areas of interest include protein, nucleic acid and lipid traffic, molecular motors, intracellular pathogens, intracellular proteolysis, nuclear import and export, cytokinesis and the cell cycle, protein translocation, antigen processing and presentation, organelle biogenesis, cell polarity and organization, and organelle movement.All aspects of the structural, molecular biology, biochemistry, genetics, morphology, intracellular signaling and relationship to hereditary or infectious diseases will be covered. Manuscripts must provide a clear conceptual or mechanistic advance. The editors will reject papers that require major changes, including addition of significant experimental data or other significant revision.Traffic will consider manuscripts of any length, but encourages authors to limit their papers to 16 typeset pages or less.